Other Treatments

Diagnosis

Other treatments, have been used in DBA over the last 30 years. These drugs appear to be largely ineffective and there is currently no evidence that any of these has a major role in the management of DBA. (Vlachos et al, 2008; Geller et al, 1975; Dunbar et al, 1991; Fiorillo et al, 1991; Niemeyer et al, 1991; Gomez-Almaguer & Gonzalez-Llano, 1992; Sumimoto et al, 1992; Bejaoui et al, 1993; Gillio et al, 1993a, 1993b; Bastion et al, 1994; Brown et al, 1994; Olivieri et al, 1994; Ozsoylu, 1994; Ball et al, 1995; Bernini et al, 1995; Buchanan, 2001; Alter, 2003)


Summary of Alternative Therapies from the International Clinical Care Consensus Document:


Treatments Number of Patients Response
Androgens >100 20%
High dose corticosteroids 12 7

8 3 complete, 1 partial

9 5 all transient
Erythropoietin 10 1 transient
Interleukin-3 100 10%
Cyclosporine ± prednisone 20 (with steroids) 50% all transient

10 (CSA alone) 2 sustained response
Metoclopromide 9 1 complete


2 partial on steroid taper

1 1 complete

33 2 partial
Valproic acid 1 1 complete
Leucine 1 1 complete
Other (6-MP, cylcophosphamide, Vincristine, stem cell factor, PIXY 321, IVIG)
Largely ineffective